Nickel-Catalyzed Carbonylative Negishi Cross-Coupling of Unactivated Secondary Alkyl Electrophiles with 1 atm CO Gas

• DOI: 10.1021/jacs.4c02023
• Publication Date: 2024-03-14T15:52:58Z
• Authors: Yetong Zhang; Qihang Cao; Yang Xi; Xianqing Wu; Jingping Qu; Yifeng Chen
• Keywords: Negishi coupling; Carbonylation; Migratory insertion

We describe a nickel-catalyzed carbonylative cross-coupling of unactivated secondary alkyl electrophiles with the organozinc reagent at atmospheric CO gas, thus allowing expedient construction unsymmetric dialkyl ketones broad functional group tolerance. The leverage newly developed