Ligand–Receptor Interaction-Induced Intracellular Phase Separation: A Global Disruption Strategy for Resistance-Free Lethality of Pathogenic Bacteria

• DOI: 10.1021/jacs.4c04749
• Publication Date: 2024-07-09T12:56:25Z
• Authors: Anming Yang; Junfeng Song; Jiaqi Li; Youzhi Li; Silei Bai; Cailing Zhou; Min Wang; Yu Zhou; Kang Wen; Miaomiao Luo; Peiren Chen; Bo Liu; Huan Yang; Yugang Bai; Wing-Leung Wong; Qingyun Cai; Huangsheng Pu; Yu Qian; Wenhao Hu; Wei Huang; Muyang Wan; Chunhui Zhang; Xinxin Feng
• Keywords: Lethality; Separation (statistics)

Addressing the global challenge of bacterial resistance demands innovative approaches, among which multitargeting is a widely used strategy. Current strategies multitargeting, typically achieved through drug combinations or single agents inherently aiming at multiple targets, face challenges such as stringent pharmacokinetic and pharmacodynamic requirements cytotoxicity concerns. In this report, we propose bacterial-specific disruption approach vastly expanded strategy that effectively disrupts subcellular organization. This effect pioneering chemical design ligand-receptor interaction-induced aggregation small molecules,