In Vitro Characterization of Kitasetaline Biosynthesis Reveals a Bifunctional P450 Decarboxylase and a Vinyl β-Carboline Intermediate Susceptible to Nonenzymatic Thiol Addition

• DOI: 10.1021/jacs.4c11552
• Publication Date: 2024-10-03T19:54:33Z
• Authors: Ziyang Zheng; Heewon Choi; Hung-wen Liu
• Keywords: Thiol; Characterization

Kitasetaline is one of the very few β-carbolines isolated from bacteria. It features a unique