Use of a New Spirophosphine To Achieve Catalytic Enantioselective [4 + 1] Annulations of Amines with Allenes To Generate Dihydropyrroles

• DOI: 10.1021/jacs.5b01944
• Publication Date: 2015-03-17T13:00:10Z
• Authors: Søren Kramer; Gregory C. Fu
• Keywords: Alkadienes; Phosphines; Pyrroles; Amines; 540; 01 natural sciences; Catalysis; 0104 chemical sciences

AbstractAn effective method for the nucleophile‐catalyzed method for the [4 + 1] annulation of sulfonamides with trisubstituted allenes to yield dihydropyrroles with good enantioselectivities is developed.