Catalytic Asymmetric [4 + 1] Annulation of Sulfur Ylides with Copper–Allenylidene Intermediates

• DOI: 10.1021/jacs.6b04414
• Publication Date: 2016-06-29T22:20:51Z
• Authors: Qiang Wang; Tian-Ren Li; Liang-Qiu Lu; Miao-Miao Li; Kai Zhang; Wen-Jing Xiao
• Keywords: 01 natural sciences; 0104 chemical sciences

AbstractCopper(II) triflate/(R,R)‐Pybox has been used as catalytic system in the synthesis of 1‐tosyl‐2‐acyl‐3‐ethynylindolins in high yields and excellent dia‐ and enantioselectivities form corresponding acylsulfur ylides and 4‐ethynyl‐1‐tosyl‐1,4‐dihydro‐2H‐benzo[d][1,3]oxazin‐2‐ones.