Multicomponent Combinatorial Polymerization via the Biginelli Reaction

• DOI: 10.1021/jacs.6b04425
• Publication Date: 2016-07-06T00:28:30Z
• Authors: Haodong Xue; Yuan Zhao; Haibo Wu; Zilin Wang; Bin Yang; Yen Wei; Zhiming Wang; Lei Tao
• Keywords: Biginelli reaction

A multicomponent combinatorial polymerization method has been exploited as a new intersection between chemistry, polymer and organic chemistry. The tricomponent Biginelli reaction employed model (MCR) to efficiently prepare library of polycondensates with continuously changed chain structure but different physical properties. naturally increased modules (monomers) directly doubled the number polymers in library, effectively improving efficiency preparation. glass transition temperatures (Tg) those homologous have mapped for first time predict Tg values absent homologues good excellent accuracy. Meanwhile, maps also used reveal regular change according (linking group, monomer length, etc.), initially suggesting academic significance system. We believe that current research paves straightforward way synthesize libraries via MCRs might prompt broader study interdisciplinary fields.