RETRACTED: Bisboronic Acids for Selective, Physiologically Relevant Direct Glucose Sensing with Surface-Enhanced Raman Spectroscopy

• DOI: 10.1021/jacs.6b07331
• Publication Date: 2016-09-26T17:51:18Z
• Authors: Bhavya Sharma; Pradeep Bugga; Lindsey R. Madison; Anne-Isabelle Henry; Martin G. Blaber; Nathan G. Greeneltch; Naihao Chiang; Milan Mrksich; George C. Schatz; Richard P. Van Duyne
• Keywords: Surface-Enhanced Raman Spectroscopy

This paper demonstrates the direct sensing of glucose at physiologically relevant concentrations with surface-enhanced Raman spectroscopy (SERS) on gold film-over-nanosphere (AuFON) substrates functionalized bisboronic acid receptors. The combination selectivity in receptor and spectral resolution SERS data allow sensors to resolve high backgrounds fructose and, multivariate statistical analysis, detect accurately 1–10 mM range. Computational modeling supports assignments normal modes vibrational frequencies for monoboronic base our acids, fructose. These results are promising use acids as receptors SERS-based vivo monitoring sensors.