Palladium-Catalyzed Intermolecular Ditrifluoromethoxylation of Unactivated Alkenes: CF3O-Palladation Initiated by Pd(IV)
01 natural sciences
0104 chemical sciences
DOI:
10.1021/jacs.7b11470
Publication Date:
2018-01-05T16:13:24Z
AUTHORS (6)
ABSTRACT
A novel palladium-catalyzed intermolecular ditrifluoromethoxylation of unactivated alkenes has been developed, using a new electrophilic reagent, SelectfluorCN, as a strong oxidant, and AgOCF3 as a trifluoromethoxide source. Preliminary mechanistic studies revealed that the reaction was possibly initiated by Pd(IV) species, and an unusual cis-addition of CF3O-Pd(IV) into the double bond leads to the formation of the first C-OCF3 bond; in addition, the second C-OCF3 bond was produced through reductive elimination at high-valent palladium center.
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