Palladium-Catalyzed Intermolecular Ditrifluoromethoxylation of Unactivated Alkenes: CF3O-Palladation Initiated by Pd(IV)

• DOI: 10.1021/jacs.7b11470
• Publication Date: 2018-01-05T16:13:24Z
• Authors: Chaohuang Chen; Yixin Luo; Liang Fu; Pinhong Chen; Yu Lan; Guosheng Liu
• Keywords: 01 natural sciences; 0104 chemical sciences

A novel palladium-catalyzed intermolecular ditrifluoromethoxylation of unactivated alkenes has been developed, using a new electrophilic reagent, SelectfluorCN, as a strong oxidant, and AgOCF3 as a trifluoromethoxide source. Preliminary mechanistic studies revealed that the reaction was possibly initiated by Pd(IV) species, and an unusual cis-addition of CF3O-Pd(IV) into the double bond leads to the formation of the first C-OCF3 bond; in addition, the second C-OCF3 bond was produced through reductive elimination at high-valent palladium center.