2-Azadienes as Reagents for Preparing Chiral Amines: Synthesis of 1,2-Amino Tertiary Alcohols by Cu-Catalyzed Enantioselective Reductive Couplings with Ketones

• DOI: 10.1021/jacs.7b12213
• Publication Date: 2017-12-22T20:26:04Z
• Authors: Kangnan Li; Xinxin Shao; Luke Tseng; Steven J. Malcolmson
• Keywords: Tertiary alcohols

We introduce a new strategy for synthesis of chiral amines: couplings α-aminoalkyl nucleophiles generated by enantioselective migratory insertion 2-azadienes to Cu-H. In this report, we demonstrate its application in catalytic reductive coupling and ketones furnish 1,2-amino tertiary alcohols with vicinal stereogenic centers.