High-Throughput Density Measurement Using Magnetic Levitation

• DOI: 10.1021/jacs.8b01283
• Publication Date: 2018-06-11T12:54:51Z
• Authors: Shencheng Ge; Yunzhe Wang; Nicolas J. Deshler; Daniel J. Preston; George M. Whitesides
• Keywords: Diamagnetism; Maglev; Magnetic Levitation

This work describes the development of an integrated analytical system that enables high-throughput density measurements diamagnetic particles (including cells) using magnetic levitation (MagLev), 96-well plates, and a flatbed scanner. MagLev is simple useful technique with which to carry out density-based analysis separation broad range materials different physical forms (e.g., liquids, solids, gels, pastes, gums, etc.); one major limitation, however, capacity perform measurements. addresses this limitation by (i) re-engineering shape fields so compatible (ii) integrating scanner (and optical components) imaging samples levitate in system. The resulting both biological (human erythrocytes) nonbiological (simple liquids such as 3-chlorotoluene, cholesterol crystals, glass beads, copper powder, polymer beads). will enable new applications chemistry materials) biochemistry cellular responses under environmental stresses) label-free format on basis universal property all matter, i.e., density.