Omnidispersible Hedgehog Particles with Multilayer Coatings for Multiplexed Biosensing

• DOI: 10.1021/jacs.8b02666
• Publication Date: 2018-05-14T14:21:36Z
• Authors: Douglas G. Montjoy; Joong Hwan Bahng; Aydin Eskafi; Harrison Hou; Nicholas A. Kotov
• Keywords: Dispersion stability

Hedgehog particles (HPs) replicating the spiky geometry of pollen grains revealed surprisingly high dispersion stability regardless whether their hydrophobicity/hydrophilicity matches that media or not. This property designated as omnidispersibility is attributed to drastic reduction van der Waals interactions between coated with stiff nanoscale spikes compared same dimensions smooth surfaces. One may hypothesize but it remains unknown, however, HPs modified polymers nanoparticles (NPs) would retain this property. Surface modifications will expand functionalities HPs, making possible utilization omnidispersible carriers. Here, we show carrying dense conformal coatings made by layer-by-layer (LBL/LbL) assembly maintain in environments extreme polarity and ionic strength. surface-modified multilayers gold NPs, are capable surface-enhanced Raman scattering (SERS) overcome limited colloidal other SERS probes. The agglomeration resilience leads a greater than one order magnitude increase intensity colloids surfaces enables simultaneous detection several targets complex Omnidispersible optically active open door for rapid multiplexed analysis biological fluids applications.