An ESIPT Probe for the Ratiometric Imaging of Peroxynitrite Facilitated by Binding to Aβ-Aggregates
Flavonoids
Amyloid beta-Peptides
Molecular Structure
Optical Imaging
Mice, Transgenic
540
01 natural sciences
543
0104 chemical sciences
3. Good health
Mice
Protein Aggregates
Peroxynitrous Acid
Animals
Protons
Fluorescent Dyes
DOI:
10.1021/jacs.8b08457
Publication Date:
2018-10-02T16:21:35Z
AUTHORS (10)
ABSTRACT
A series of 3-hydroxyflavone (3-HF) ESIPT (excited-state intramolecular proton transfer) boronate-based fluorescent probes have been developed for the detection peroxynitrite (ONOO–). The dyes are environmentally sensitive, and each probe exhibited a ratiometric response toward ONOO– in micellar environment. were used to image different aggregation states amyloid-β (Aβ) presence ONOO–. 3-HF-OMe was found produce when bound Aβ aggregates, resulting novel host–guest ensemble, which adds insight into development other ESIPT-based simultaneous sensing fibrous proteins/peptides environmental ROS/RNS.
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