An ESIPT Probe for the Ratiometric Imaging of Peroxynitrite Facilitated by Binding to Aβ-Aggregates

Flavonoids Amyloid beta-Peptides Molecular Structure Optical Imaging Mice, Transgenic 540 01 natural sciences 543 0104 chemical sciences 3. Good health Mice Protein Aggregates Peroxynitrous Acid Animals Protons Fluorescent Dyes
DOI: 10.1021/jacs.8b08457 Publication Date: 2018-10-02T16:21:35Z
ABSTRACT
A series of 3-hydroxyflavone (3-HF) ESIPT (excited-state intramolecular proton transfer) boronate-based fluorescent probes have been developed for the detection peroxynitrite (ONOO–). The dyes are environmentally sensitive, and each probe exhibited a ratiometric response toward ONOO– in micellar environment. were used to image different aggregation states amyloid-β (Aβ) presence ONOO–. 3-HF-OMe was found produce when bound Aβ aggregates, resulting novel host–guest ensemble, which adds insight into development other ESIPT-based simultaneous sensing fibrous proteins/peptides environmental ROS/RNS.
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