Direct Carbon Isotope Exchange through Decarboxylative Carboxylation
Carboxylation
Kinetic isotope effect
Carbon-14
Decarboxylation
Carbon fibers
DOI:
10.1021/jacs.8b12035
Publication Date:
2019-01-03T20:30:01Z
AUTHORS (8)
ABSTRACT
A two-step degradation–reconstruction approach to the carbon-14 radiolabeling of alkyl carboxylic acids is presented. Simple activation via redox-active ester formation was followed by nickel-mediated decarboxylative carboxylation afford a range complex compounds with ample isotopic incorporations for drug metabolism and pharmacokinetic studies. The practicality operational simplicity protocol were demonstrated its use in an industrial setting.
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