Isotope Labeling Reveals Fast Atomic and Molecular Exchange in Mechanochemical Milling Reactions

H/D exchange Chemistry in situ monitoring isotope labeling ; mechanochemistry ; mechanochemical deuteration ; in situ monitoring ; solid-state diffusion ; H/D exchange mechanochemical deuteration solid-state diffusion isotope labeling mechanochemistry Physical Chemistry 01 natural sciences 0104 chemical sciences
DOI: 10.1021/jacs.8b12149 Publication Date: 2019-01-04T18:41:57Z
ABSTRACT
Using tandem in situ monitoring and isotope-labeled solids, we reveal that mechanochemical ball-milling overcomes inherently slow solid-state diffusion through continuous comminution and growth of milled particles. This process occurs with or without a net chemical reaction and also occurs between solids and liquid additives that can be practically used for highly efficient deuterium labeling of solids. The presented findings reveal a fundamental aspect of milling reactions and also delineate a methodology that should be considered in the study of mechanochemical reaction mechanisms.
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