Isotope Labeling Reveals Fast Atomic and Molecular Exchange in Mechanochemical Milling Reactions

• DOI: 10.1021/jacs.8b12149
• Publication Date: 2019-01-04T18:41:57Z
• Authors: Stipe Lukin; Martina Tireli; Tomislav Stolar; Dajana Barišić; Maria Valeria Blanco; Marco di Michiel; Krunoslav Užarević; Ivan Halasz
• Keywords: H/D exchange; Chemistry; in situ monitoring; isotope labeling ; mechanochemistry ; mechanochemical deuteration ; in situ monitoring ; solid-state diffusion ; H/D exchange; mechanochemical deuteration; solid-state diffusion; isotope labeling; mechanochemistry; Physical Chemistry; 01 natural sciences; 0104 chemical sciences

Using tandem in situ monitoring and isotope-labeled solids, we reveal that mechanochemical ball-milling overcomes inherently slow solid-state diffusion through continuous comminution and growth of milled particles. This process occurs with or without a net chemical reaction and also occurs between solids and liquid additives that can be practically used for highly efficient deuterium labeling of solids. The presented findings reveal a fundamental aspect of milling reactions and also delineate a methodology that should be considered in the study of mechanochemical reaction mechanisms.