Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling

• DOI: 10.1021/jacs.9b07512
• Publication Date: 2019-08-21T13:50:22Z
• Authors: Franco Della-Felice; Ariel M. Sarotti; Michael J. Krische; Ronaldo A. Pilli
• Keywords: Coupling reaction

The first total synthesis and structural validation of phosdiecin A was accomplished in 13 steps through asymmetric iridium-catalyzed alcohol-mediated carbonyl reductive coupling. present route is the shortest among >30 formal syntheses fostriecin family members.