Water-Soluble Flexible Organic Frameworks That Include and Deliver Proteins

• DOI: 10.1021/jacs.9b13263
• Publication Date: 2020-02-03T15:21:05Z
• Authors: Jia-Le Lin; Ze-Kun Wang; Zi-Yue Xu; Lei Wei; Yun-Chang Zhang; Hui Wang; Dan-Wei Zhang; Wei Zhou; Yue-Biao Zhang; Yi Liu; Zhan-Ting Li
• Keywords: Water soluble

Four water-soluble hydrazone-based three-dimensional (3D) flexible organic frameworks FOF-1–4 have been synthesized from a semirigid tetracationic tetraaldehyde and four dihydrazides. 1H NMR spectroscopy indicated the quantitative formation of in D2O, while dynamic light scattering experiments revealed that, depending on concentration, these porous display hydrodynamic diameters ranging 50 to 120 nm. The porosity is confirmed by ethanol vapor adsorption solid samples as well high loading capacity for 2.3 nm porphyrin guest water. new exhibit low cytotoxicity form inherent pores with 5.3 or 6.7 nm, allowing rapid inclusion proteins such bovine serum albumin green orange fluorescent proteins, efficient delivery into normal cancer cells. Flow cytometric analysis reveals percentages delivered cells up 99.8%.