Broadly Neutralizing Synthetic Cannabinoid Vaccines

• DOI: 10.1021/jacsau.0c00057
• Publication Date: 2020-12-15T18:15:23Z
• Authors: Mingliang Lin; Jinny Claire Lee; Steven Blake; Beverly Ellis; Lisa M. Eubanks; Kim D. Janda
• Keywords: Hapten; Synthetic cannabinoids

Synthetic cannabinoids (SCs) constitute a significant portion of psychoactive substances forming major public health risk. Due to the wide variety SCs, broadly neutralizing antibodies generated by active immunization present an intriguing pathway combat cannabinoid use disorder. Here, we probed hapten design for antibody affinity and cross reactivity against two classes SCs. Of 10 haptens screened, 3 vaccine groups revealed submicromolar IC50, each targeting 5–6 compounds in our panel 22 drugs. Moreover, SCs were successfully sequestered when administered vaping or intraperitoneal injection, which was confirmed within animal models observing locomotion, body temperature, pharmacokinetics. We also discovered synergistic effects simultaneously blunt drug through admixture approach. Collectively, study provides comprehensive foundation development vaccines