Use of Diagnostic Ions for the Detection of Fentanyl Analogs in Human Matrices by LC–QTOF

Fentanyl Ions Synthetic Drugs Tandem Mass Spectrometry Humans 01 natural sciences 6. Clean water Chromatography, Liquid 0104 chemical sciences
DOI: 10.1021/jasms.1c00267 Publication Date: 2021-11-18T17:32:56Z
ABSTRACT
To combat the ongoing opioid epidemic, our laboratory has developed and evaluated an approach to detect fentanyl analogs in urine plasma by screening LC–QTOF MS/MS spectra for ions that are diagnostic of core structure. data from a training set 142 were used select four product six neutral losses together provided most complete coverage (97.2%) compounds. Furthermore, using ion screen against 49 not resulted 95.9% those With this approach, lower reportable limits subset fentanyl-related compounds range 0.25 2.5 ng/mL 0.5 5.0 plasma. This innovative processing method was applied evaluate simulated exposure samples remifentanil carfentanil water their metabolites acid norcarfentanil urine. flexible enables way emerging clinical samples.
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