Use of Diagnostic Ions for the Detection of Fentanyl Analogs in Human Matrices by LC–QTOF
Fentanyl
Ions
Synthetic Drugs
Tandem Mass Spectrometry
Humans
01 natural sciences
6. Clean water
Chromatography, Liquid
0104 chemical sciences
DOI:
10.1021/jasms.1c00267
Publication Date:
2021-11-18T17:32:56Z
AUTHORS (6)
ABSTRACT
To combat the ongoing opioid epidemic, our laboratory has developed and evaluated an approach to detect fentanyl analogs in urine plasma by screening LC–QTOF MS/MS spectra for ions that are diagnostic of core structure. data from a training set 142 were used select four product six neutral losses together provided most complete coverage (97.2%) compounds. Furthermore, using ion screen against 49 not resulted 95.9% those With this approach, lower reportable limits subset fentanyl-related compounds range 0.25 2.5 ng/mL 0.5 5.0 plasma. This innovative processing method was applied evaluate simulated exposure samples remifentanil carfentanil water their metabolites acid norcarfentanil urine. flexible enables way emerging clinical samples.
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