A Dietary Resveratrol-Rich Grape Extract Prevents the Developing of Atherosclerotic Lesions in the Aorta of Pigs Fed an Atherogenic Diet

• DOI: 10.1021/jf301154q
• Publication Date: 2012-05-18T10:49:50Z
• Authors: María Azorín-Ortuño; María Josefa Yañé...; Francisco J. Pall...; José Rivera; Antonio González-...; Mar Larrosa; Fernando Vallejo; María Teresa Garc...; Francisco Tomás-B...; Juan Carlos Espín
• Keywords: Male; 2. Zero hunger; 0303 health sciences; Plant Extracts; Swine; In Vitro Techniques; Atherosclerosis; 3. Good health; Disease Models, Animal; 03 medical and health sciences; Resveratrol; Stilbenes; Animals; Diet, Atherogenic; Humans; Swine, Miniature; Female; Vitis; Aorta

The presence of grape and wine polyphenol resveratrol (RES) in the diet is negligible. Therefore, cardiovascular benefits this molecule, a dietary context, remain to be established. We aimed investigate, through intervention, effects resveratrol-rich extract (GE-RES) on prevention early aortic lesions pigs fed an atherogenic (AD). These were compared with those produced by lacking RES (GE) or alone. Pigs AD for 4 months showed atherosclerotic thoracic aorta: degeneration fragmentation elastic fibers, increase intima thickness, subendothelial fibrosis, accumulation fatty cells anion superoxide radicals. GE-RES was most effective treatment prevented disruption decreased their alteration (57%), reduced thickness (33%) (42%) O(2)(•-) (38%) tissue. In addition, moderately downregulated expression suppressors cytokine signaling 1 (SOCS1) 3 (SOCS3), key regulators vascular cell responses, peripheral mononuclear blood cells. Our results suggest that consumption nutraceutical, could prevent events. strengthened these effects.