Synthesis and Fungicidal Activities of Novel Indene-Substituted Oxime Ether Strobilurins

• DOI: 10.1021/jf800273t
• Publication Date: 2008-06-12T09:00:59Z
• Authors: Song Tu; Long-He Xu; Li-Yi Ye; Xi Wang; Yong Sha; Zong-Yuan Xiao
• Keywords: Pyricularia; Strobilurin; Phytophthora infestans; Indene; Pseudoperonospora cubensis

Nineteen novel indene-substituted oxime ether strobilurins, which used an indene group to stabilize the ( E)-styryl in SYP-Z071 (an unsaturated strobilurin fungicide under development by Shenyang Research Institute of Chemical Industry), were designed and synthesized. The biological assay results showed that all compounds possessed good or excellent fungicidal activities. It was found most higher activities against Pyricularia oryzae, Phytophthora infestans, Erysiphe graminis, Colletotrichum lagenarium than at tested concentration. also indicated exhibited vivo cucumber Pseudoperonospora cubensis C. commercial fungicides trifloxystrobin kresoxim-methyl a concentration 6.25 mg/L. Furthermore, it alpha-(methoxyimino)- N-methylphenylacetamide ethers 6m- s broad spectrum remarkably fungi. Especially, 6-methylindene-substituted compound 6p identified as promising candidate for further study.