A Peptide Nucleic Acid−Neamine Conjugate That Targets and Cleaves HIV-1 TAR RNA Inhibits Viral Replication

• DOI: 10.1021/jm049642d
• Publication Date: 2004-09-16T04:21:33Z
• Authors: Emmanuel Riguet; Snehlata Tripathi; Binay Chaubey; Jérôme Désiré; Virendra N. Pandey; Jean-Luc Décout
• Keywords: Conjugate; Peptide nucleic acid; tar (computing); Replication

The neamine part of the aminoglycoside antibiotic neomycin B was conjugated to a 16 mer peptide nucleic acid (PNA) targeting HIV-1 TAR RNA. Attachment core allows cellular uptake PNA and results in potent inhibition replication. polycationic moiety imparts greater solubility also confers unique RNA cleavage property conjugate which is specific its target site functional at physiological concentrations Mg2+. These properties suggest potential therapeutic application for this class compounds.