Inhibition of Acetylcholinesterase, β-Amyloid Aggregation, and NMDA Receptors in Alzheimer’s Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush

• DOI: 10.1021/jm800577j
• Publication Date: 2008-07-08T07:00:46Z
• Authors: Michela Rosini; Elena Simoni; Manuela Bartolini; Andrea Cavalli; Luisa Ceccarini; Nicoleta Pascu; David W. McClymont; Andrea Tarozzi; Maria L. Bolognesi; Anna Minarini; Vincenzo Tumiatti; Vincenza Andrisano; Ian R. Mellor; Carlo Melchiorre
• Keywords: β amyloid

Alzheimer's disease (AD) is a multifactorial syndrome with several target proteins contributing to its etiology. To confront AD, an innovative strategy design single chemical entities able simultaneously modulate more than one target. Here, we present compounds that inhibit acetylcholinesterase and NMDA receptor activity. Furthermore, these AChE-induced Aβ aggregation display antioxidant properties, emerging as lead candidates for treating AD.