Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development

• DOI: 10.1021/jm900786r
• Publication Date: 2009-09-24T16:39:09Z
• Authors: Mark D. Wittman; Joan M. Carboni; Zheng Yang; Francis Y. Lee; Melissa Antman; Ricardo Attar; Praveen Balimane; Chiehying Chang; Cliff Chen; Lorell Discenza; David Frennesson; Marco M. Gottardis; Ann Greer; Warren Hurlburt; Walter Johnson; David R. Langley; Aixin Li; Jianqing Li; Peiying Liu; Harold Mastalerz; Arvind Mathur; Krista Menard; Karishma Patel; John Sack; Xiaopeng Sang; Mark Saulnier; Daniel Smith; Kevin Stefanski; George Trainor; Upender Velaparthi; Guifen Zhang; Kurt Zimmermann; Dolatrai M. Vyas
• Keywords: Triazine

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTDiscovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical DevelopmentMark D. Wittman*‡, Joan M. Carboni⊥, Zheng Yang#, Francis Y. Lee⊥, Melissa Antman∞, Ricardo Attar⊥, Praveen Balimane#, Chiehying Chang×, Cliff Chen⊥, Lorell Discenza⊥, David Frennesson‡, Marco Gottardis⊥, Ann Greer⊥, Warren Hurlburt⊥, Walter Johnson‡, R. Langley§, Aixin Li⊥, Jianqing Li∥, Peiying Liu‡, Harold Mastalerz‡, Arvind Mathur●, Krista Menard⊥, Karishma Patel#, John Sack×, Xiaopeng Sang‡, Mark Saulnier‡, Daniel Smith∥, Kevin Stefanski∞, George Trainor◆, Upender Velaparthi‡, Guifen Zhang‡, Kurt Zimmermann‡, and Dolatrai Vyas‡View Author Information‡ Discovery Chemistry§ Macromolecular Structure∥ Department Chemical Synthesis Bristol-Myers Squibb Co., 5 Research Parkway, Wallingford, Connecticut 06492⊥ Oncology Drug Discovery# Metabolism Pharmacokinetics× Structure∞ Pharmacuetics● Synthesis◆ Chemistry Route 206 Province Line Road, Princeton, New Jersey 08540*To whom correspondence should be addressed. Phone: [phone]. Fax: [phone]. E-mail: [email protected]Cite this: J. Med. Chem. 2009, 52, 23, 7360–7363Publication Date (Web):September 24, 2009Publication History Received2 June 2009Published online24 September inissue 10 December 2009https://pubs.acs.org/doi/10.1021/jm900786rhttps://doi.org/10.1021/jm900786rrapid-communicationACS PublicationsCopyright © 2009 American SocietyRequest reuse permissionsArticle Views5098Altmetric-Citations79LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting SUBJECTS:Amides,Inhibition,Inhibitors,Peptides proteins,Rodent models Get e-Alerts