Ipso- or Cine-Substitutions of 6-Haloimidazo[1,2-a]pyridine Derivatives with Different Azoles Depending on the Reaction Conditions

• DOI: 10.1021/jo034439w
• Publication Date: 2003-07-03T04:52:49Z
• Authors: Cécile Enguehard; Hassan Allouchi; Alain Gueiffier; Stephen L. Buchwald
• Keywords: Reactivity; Dimethyl formamide; Substitution (logic); Substitution reaction

The reactivity of 6-haloimidazo[1,2-a]pyridine toward different azoles is reported. process was shown to be highly dependent on the reaction conditions. Using copper(I) catalyst, product ipso substitution obtained. In absence copper, with cesium carbonate in N,N-dimethylformamide, a cine took place.