Enyne versus Diene RCM in the Synthesis of Cyclopentene Derivatives toward the A Ring of FR182877

• DOI: 10.1021/jo049557d
• Publication Date: 2004-06-18T04:28:33Z
• Authors: Jacques-Alexis Funel; Joëlle Prunet
• Keywords: Cyclopentene; Enyne metathesis; Enyne; Diene

The A ring of FR182877, exemplified by ent-4-b,c, has been synthesized, involving an enyne RCM as the key step. systematic comparison vs diene for formation cyclopentene derivatives showed that latter metathesis proceeds much more easily even this size.