Total Synthesis of Unguisin A
Molecular Conformation
Stereoisomerism
Peptides, Cyclic
01 natural sciences
gamma-Aminobutyric Acid
0104 chemical sciences
DOI:
10.1021/jo200813a
Publication Date:
2011-05-25T22:44:31Z
AUTHORS (2)
ABSTRACT
The first synthesis of the γ-aminobutyric acid (GABA)-containing cyclic heptapeptide unguisin A is reported, confirming the structure of this natural product. Macrocyclization of a flexible GABA-containing linear precursor is found to proceed rapidly and in good yield.
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