Three Rhodamine-Based “Off–On” Chemosensors with High Selectivity and Sensitivity for Fe3+ Imaging in Living Cells

Spectrophotometry, Infrared Nitrogen Rhodamines Iron Ferric Compounds Sensitivity and Specificity 01 natural sciences Chemistry Techniques, Analytical Molecular Imaging 0104 chemical sciences Oxygen Microscopy, Electron, Scanning Humans Benzothiazoles Fluorescent Dyes HeLa Cells
DOI: 10.1021/jo202056t Publication Date: 2011-12-17T16:04:15Z
ABSTRACT
Three new rhodamine-based probes Y1-Y3 were synthesized as "off-on" chemosensors for Fe(3+) imaging in living cells. The recognizing behaviors were investigated both experimentally and computationally. The crystal structure of the complex Y3-Fe(3+) revealed that Fe(3+) preferred to coordinate with the N atom of benzothiazole moiety rather than the O atom of carboxyl group.
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