Epoxidation of Olefins with a Silica-Supported Peracid in Supercritical Carbon Dioxide under Flow Conditions

• DOI: 10.1021/jo300532f
• Publication Date: 2012-04-25T13:22:35Z
• Authors: Rossella Mello; Ana Alcalde-Aragonés; Andrea Olmos; María Elena Gonzá...; Gregorio Asensio
• Keywords: 01 natural sciences; 0104 chemical sciences

Anhydrous 2-percarboxyethyl-functionalized silica (2b), a recyclable supported peracid, is a suitable reagent to perform the epoxidation of alkenes 1 in supercritical carbon dioxide at 250 bar and 40 °C under flow conditions. This procedure simplifies the isolation of the reaction products and uses only carbon dioxide as a solvent under mild conditions. The solid reagent 2b can be easily recycled by a reaction with 30% hydrogen peroxide in an acid medium.