Highly Enantioselective Fluorination of Unprotected 3-Substituted Oxindoles: One-Step Synthesis of BMS 204352 (MaxiPost)

• DOI: 10.1021/jo301705t
• Publication Date: 2012-10-02T18:28:38Z
• Authors: Jun Li; Yunfei Cai; Weiliang Chen; Xiaohua Liu; Lili Lin; Xiaoming Feng
• Keywords: Models, Molecular; Indoles; Molecular Structure; Stereoisomerism; Crystallography, X-Ray; 01 natural sciences; Oxindoles; 0104 chemical sciences

AbstractIn the presence of Sc(OTf)3 and the chiral N‐oxides (NDO) and (LIG) a number of unprotected 3‐substituted oxindoles undergoes efficient fluorination to afford 3‐fluorooxindole derivatives with high enantioselectivty.