Iron-Catalyzed Arylalkoxycarbonylation of N-Aryl Acrylamides with Carbazates

• DOI: 10.1021/jo402529r
• Publication Date: 2013-12-16T10:23:18Z
• Authors: Xiangsheng Xu; Yucai Tang; Xiaoqing Li; Guo Hong; Mingwu Fang; Xiaohua Du
• Keywords: Acrylamides; Hydrazines; Indoles; Molecular Structure; Iron; 01 natural sciences; Catalysis; 0104 chemical sciences

A novel arylalkoxycarbonylation of N-aryl acrylamides with carbazates leading to alkoxycarbonylated oxindoles has been developed. The reported reactions employ economical and environmentally benign FeCl2·4H2O as a catalyst easily accessible safe alkoxycarbonyl radical precursors.