Diversity-Oriented Synthesis of Ketoindoloquinoxalines and Indolotriazoloquinoxalines from 1-(2-Nitroaryl)-2-alkynylindoles

• DOI: 10.1021/jo402783p
• Publication Date: 2014-02-26T21:06:38Z
• Authors: Srinivas Samala; Rajesh K Arigela; Ruchir Kant; Bijoy Kundu
• Keywords: Indoles; Cycloaddition Reaction; Quinoxalines; Heterocyclic Compounds, 4 or More Rings; 01 natural sciences; Catalysis; 0104 chemical sciences

A one-pot protocol for the diversity-oriented synthesis of two indole-based annulated polyheterocycles, ketoindoloquinoxalines and indolotriazoloquinoxalines, has been described. The salient features of the methodology involves either a metal/O2-catalyzed aminooxygenation or a [3 + 2] cycloaddition pathway.