Electrochemical Access to 8-(1-Phenyl-ethyl)-1,4-dioxa-8-aza-spiro[4.5]decane-7-carbonitrile. Application to the Asymmetric Syntheses of (+)-Myrtine and Alkaloid (+)-241D

• DOI: 10.1021/jo500104c
• Publication Date: 2014-03-26T15:56:55Z
• Authors: Van Ha Vu; Fadila Louafi; Nicolas Girard; Ronan Marion; Thierry Roisnel; Vincent Dorcet; Jean-Pierre Hurvois
• Keywords: Magnetic Resonance Spectroscopy; Molecular Structure; Stereoisomerism; 01 natural sciences; Catalysis; 0104 chemical sciences; Alkaloids; Nitriles; Electrochemistry; [CHIM]Chemical Sciences; Spiro Compounds; Quinolizines

AbstractElectrochemical cyanation of the piperidine (I) allows effective synthesis of the α‐amino nitrile (III).