Copper-Catalyzed Synthesis of Substituted Quinolines via C–N Coupling/Condensation from ortho-Acylanilines and Alkenyl Iodides

• DOI: 10.1021/jo502630t
• Publication Date: 2014-12-15T21:21:10Z
• Authors: Lingkai Kong; Yuanyuan Zhou; He Huang; Yang Yang; Yuanyuan Liu; Yanzhong Li
• Keywords: Enamine; Ullmann reaction

An efficient cascade copper-catalyzed intermolecular Ullmann-type C–N coupling/enamine condensation reaction is described, in which ortho-acylanilines and alkenyl iodides converted to multisubstituted quinolines good excellent yields.