Novel Method To Investigate the Interaction Force between Etoposide and APTES-Functionalized Fe3O4@nSiO2@mSiO2 Nanocarrier for Drug Loading and Release Processes

• DOI: 10.1021/jp512447s
• Publication Date: 2015-02-11T12:04:36Z
• Authors: Weiwei Zhao; Bin Cui; Hongxia Peng; Hongjin Qiu; Yaoyu Wang
• Keywords: Nanocarriers; Isothermal microcalorimetry; Superparamagnetism

We report a 3-aminopropyltriethoxysilane (APTES) functionalized magnetic core–shell structure drug delivery system which is composed of nonmesporous silica (nSiO2) coated Fe3O4 nanoparticle as the core and mesoporous (mSiO2) shell (designated Fe3O4@nSiO2@mSiO2-APTES). These spheres have superparamagnetism, high magnetization (39.1 emu/g), large surface area (222.35 m2/g), uniform accessible mesopores (2.5 nm), abundant amino groups on shell. investigated thermodynamic kinetic properties for loading release processes using microcalorimetry first time. The process was exothermal, endothermal. A series thermodynamics parameters ΔH, ΔS, ΔG calculated. For process, critical value determined, kinetics equation dα/dt = 10–3.66(1 – a)1.01, rate constant k 10–3.66 s–1 also obtained. results show that interaction between molecule nanocarrier hydrogen-bond derived from experimental values molar enthalpies (ΔH < 0) entropy (ΔS 0). This method therefore promise to provide theoretical basis nanocarrier, so guide an externally controlled drug-delivery in cancer therapy.