Facile Solvothermal Preparation of Monodisperse Gold Nanoparticles and Their Engineered Assembly of Ferritin–Gold Nanoclusters

• DOI: 10.1021/la403888f
• Publication Date: 2013-11-28T01:06:59Z
• Authors: Jonghoon Choi; Sungwook Park; Zoran Stojanović; Hyung-Seop Han; Jongwook Lee; Hyun Kwang Seok; Dragan Uskoković; Kwan Hyi Lee
• Keywords: Oleylamine; Chloroauric acid; Sodium borohydride

Herein, we report a quick and simple synthesis of water-soluble gold nanoparticles using HAuCl4 oleylamine mixture. Oleylamine serves as reduction agent well stabilizer for nanoparticle surfaces. The particle sizes can be adjusted by modulating reaction temperature time. Solvothermal with confirmed measuring the product in Fourier transform infrared (FTIR) spectroscopy. plasmon band shifting from yellow to red confirms nanosized formation. Amide bonds on surface formed hydrogen one another, resulting hydrophobic monolayer. Particles dispersed nonpolar organic solvents, such hexane or toluene, brief sonication. Next, demonstrated transfer into water lipid capsulation 1-myristoyl-2-hydroxy-sn-glycero-3-phosphocholine (MHPC), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(methoxy polyethylene glycol)-2000 (DPPE-PEG2k), 1,2-dioleoyl-sn-glycero-3-N-{5-amino-1-carboxypentyl}iminodiacetic acid succinyl nickel salt [DGS-NTA(Ni)]. concentration obtained an absorbance ultraviolet–visible (UV–vis) spectra (at 420 nm). Instrumental analyses transmission electron microscopy (TEM), energy-dispersive X-ray (EDX) analysis, dynamic light scattering (DLS), FTIR successful production fair solubility water. Prepared particles were selectively clustered via engineered ferritin nanocages that provide multiple conjugation moieties. A total 5–6 single nanocage TEM. Reported solvothermal preparation nanoclusters may serve efficient, alternate way preparing nanoparticles, which used wide variety biomedical applications.