Probing Influence of Mesophasic Transformation on Performance of Self-Emulsifying System: Effect of Ion

• DOI: 10.1021/mp200541r
• Publication Date: 2012-01-05T09:59:49Z
• Authors: Sharvil S. Patil; Edakkal Venugopal; Suresh Bhat; Kakasaheb R. Mahadik; Anant R. Paradkar
• Keywords: Small-angle X-ray scattering

Self-emulsifying systems are mixtures of oils and surfactants, ideally isotropic, sometimes including cosolvents, which emulsify under conditions gentle agitation, similar to those would be encountered in the gastrointestinal tract. The process self-emulsification has remained center attraction for most researchers. Controlled hydration self-emulsifying shows formation an intermediate gel phase upon rupture forms emulsion. Current work was undertaken understand explore microstructural properties believed influence performance (droplet size) final formulation. effect additives on also been investigated. Microstructural elucidation hydrated samples regimes done by using techniques such as small angle X-ray scattering, differential scanning calorimetry rheology. Samples from showed local lamellar structure swelled with hydration. In present work, addition salt form naproxen (sodium potassium) (base) Systems containing salts formed larger droplets whereas base smaller ones. structures were well correlated current studies indicate that controlling optimized formulations desired can tailor-made.