Efficient Simultaneous Tumor Targeting Delivery of All-Trans Retinoid Acid and Paclitaxel Based on Hyaluronic Acid-Based Multifunctional Nanocarrier

• DOI: 10.1021/mp3005808
• Publication Date: 2013-01-15T20:26:05Z
• Authors: Jing Yao; Li Zhang; Jianping Zhou; Hongpan Liu; Qiang Zhang
• Keywords: Nanocarriers; Conjugate

An amphiphilic hyaluronic acid (HA)-g-all-trans retinoid (HRA) conjugate was successfully developed as a tumor-targeting nanocarrier for potentially synergistic combination chemotherapy of all-trans (ATRA) and paclitaxel (PTX). The HRA synthesized by an imine reaction between HA-COOH ATRA-NH2. PTX-loaded nanoparticles possessed high loading capacity, nanoscale particle sizes, good biocompatible characteristics. Cell viability assays indicated that exhibited concentration- time-dependent cytotoxicity. Moreover, they displayed obvious superiority in inducing the apoptosis tumor cells. Cellular uptake analysis suggested could be efficiently taken up cells via endocytic pathway transport into nucleus, contributing to HA receptor-mediated endocytosis ATRA-induced nuclear translocation, respectively. vivo imaging accumulation DiR-loaded increased obviously after intravenous administration compared free DiR solution, which confirmed assist drugs targeting tumor. Furthermore, greater growth inhibition effect with reducing toxicity. Therefore, can considered promising targeted codelivery system cancer chemotherapy.