Digestion of Phospholipids after Secretion of Bile into the Duodenum Changes the Phase Behavior of Bile Components

• DOI: 10.1021/mp500193g
• Publication Date: 2014-07-02T23:20:31Z
• Authors: Woldeamanuel A. B...; Dallas B. Warren; Ahmed Ibrahim; Hywel D. Williams; Hassan Benameur; Christopher J. H....; David K. Chalmers; Colin W. Pouton
• Keywords: Lipid digestion; Digestion

Bile components play a significant role in the absorption of dietary fat, by solubilizing products fat digestion. The poorly water-soluble drugs from gastrointestinal tract is often enhanced interaction with pathways digestion and absorption. These processes can enhance drug Thus, phase behavior bile digested lipids great interest to pharmaceutical scientists who seek optimize solubilization gut lumen. This be achieved dosing after food or preferably formulating lipid-based delivery system. Phase diagrams salts, lecithin, water have been available for many years, but here we investigate association structures that occur dilute aqueous solution, concentrations are present More importantly, compared these those would expected intestine soon secretion bile. Phosphatidylcholines rapidly hydrolyzed pancreatic enzymes yield equimolar mixtures their monoacyl equivalents fatty acids. We constructed model formed biliary phospholipids. micelle-vesicle boundary was clearly identifiable dynamic light scattering nephelometry. data indicate significantly higher molar ratio lipid salt required cause transition lamellar (i.e., liposomes solution). Mixed micelles capacity different solubilize lipophilic drugs. suggest lysolecithin, acid, salts better molecular associations lumen, such could used understand pathway.