DNA-Mediated Fluctuations in Ionic Current through Silicon Oxide Nanopore Channels

• DOI: 10.1021/nl049267c
• Publication Date: 2004-08-11T05:07:08Z
• Authors: H. Chang; F. Kosari; G. Andreadakis; M. A. Alam; G. Vasmatzis; R. Bashir
• Keywords: Nanopore; Biomolecule; Silicon oxide

Single molecule sensors in which nanoscale pores within biological or artificial membranes act as mechanical gating elements are very promising devices for the rapid characterization and sequencing of nucleic acid molecules. The two terminal electrical measurements translocation polymers through single ion channels that ssDNA molecules protein have been demonstrated, sparked tremendous interest such sensors. prevailing view regarding nanopore is there exists no interaction between translocating molecule, all reported to-date, whether artificial, operate a coulter-counter, i.e., ionic current measured across pore decreases (is mechanically blocked) when DNA transverses pore. We fabricated "channel" with silicon oxide inner surface, our results challenge exclusive during dsDNA these channels. demonstrate can actually increase due to surface channel charge on itself.