Achieving a New Controllable Male Contraception by the Photothermal Effect of Gold Nanorods

• DOI: 10.1021/nl400536d
• Publication Date: 2013-05-20T19:56:45Z
• Authors: Wen-qing Li; Chun-yang Sun; Feng Wang; Yu-cai Wang; Yi-wen Zhai; Meng Liang; Wen-jing Liu; Zhi-min Liu; Jun Wang; Fei Sun
• Keywords: Sterilization; Male contraceptive

During the process of human civilization, owning household pets has become increasingly popular. However, dogs and cats may be reservoirs or vectors transmissible diseases to humans. Confronted with overpopulation pets, traditional contraception methods, surgical methods sterilization, for animals are used, namely, ovariohysterectomy orchidectomy. Therefore, a simple, nonsurgical, controllable, more effective less expensive method is highly desirable. In this study, we show that in situ testicular injection methoxy poly(ethylene glycol)-modified gold nanorods near-infrared irradiation male mice can achieve short-lived permanent infertility. lower hyperthermia treatment, morphology testes seminiferous tubules only partly injured, fertility indices decreased 10% at day 7, then recovered 50% 60. higher totally destroyed, 0 7. Overall, our results indicate potential application plasmonic nanomaterials contraception.