Multifunctional Rare-Earth Vanadate Nanoparticles: Luminescent Labels, Oxidant Sensors, and MRI Contrast Agents

• DOI: 10.1021/nn504170x
• Publication Date: 2014-10-07T19:26:08Z
• Authors: Mouna Abdesselem; Markus Schoeffel; Isabelle Maurin; Rivo Ramodiharilafy; Gwennhael Autret; Olivier Clément; Pierre-Louis Tharaux; Jean-Pierre Boilot; Thierry Gacoin; Cedric Bouzigues; Antigoni Alexandrou
• Keywords: Vanadate; MRI contrast agent

Collecting information on multiple pathophysiological parameters is essential for understanding complex pathologies, especially given the large interindividual variability. We report here multifunctional nanoparticles which are luminescent probes, oxidant sensors, and contrast agents in magnetic resonance imaging (MRI). Eu(3+) ions an yttrium vanadate matrix have been demonstrated to emit strong, nonblinking, stable luminescence. Time- space-resolved optical detection feasible after reversible photoreduction of Eu(2+) reoxidation by oxidants, such as H2O2, leading a modulation luminescence emission. The incorporation paramagnetic Gd(3+) confers addition proton relaxation enhancing properties system. synthesized characterized either 5 or 30 nm diameter with compositions GdVO4 Gd0.6Eu0.4VO4. These particles retain YVO4:Eu. Moreover, relaxivity Gd0.6Eu0.4VO4 higher than that commercial chelate compound Dotarem at 20 MHz. Nuclear dispersion spectroscopy showed increase above 10 Complexometric titration indicated rare-earth leaching negligible. injected mice were observed MRI concentrate liver bladder min. Thus, these pave way simultaneous detection, particular, vivo localization evolution reactive oxygen species broad range physiological conditions.