Characterization of Antiplatelet Properties of Silver Nanoparticles

• DOI: 10.1021/nn900277t
• Publication Date: 2009-05-04T14:33:42Z
• Authors: Siddhartha Shriva...; Tanmay Bera; Sunil K. Singh; Gajendra Singh; P. Ramachandrarao; Debabrata Dash
• Keywords: Lytic cycle

Thrombotic disorders have emerged as serious threat to society. As anticoagulant and thrombolytic therapies are usually associated with bleeding complications, the focus has now shifted regulating maintaining platelets in an inactive state. In present study we show that nanosilver innate antiplatelet property effectively prevents integrin-mediated platelet responses, both vivo vitro, a concentration-dependent manner. Ultrastructural studies accumulates within granules reduces interplatelet proximity. Our findings further suggest these nanoparticles do not confer any lytic effect on thus hold potential be promoted antiplatelet/antithrombotic agents after careful evaluation of toxic effects.