Structural Activity Relationship Studies of Zebra Mussel Antifouling and Antimicrobial Agents from Verongid Sponges

• DOI: 10.1021/np040097t
• Publication Date: 2004-12-28T12:18:53Z
• Authors: Jeffrey A. Diers; Hari Kishore Pennaka; Jiangnan Peng; John J. Bowling; Stephen O. Duke; Mark T. Hamann
• Keywords: Biofouling; Sponge; Zebra mussel

Several dibromotyramine derivatives including moloka'iamine were selected as potential zebra mussel (Dreissena polymorpha) antifoulants due to the noteworthy absence of fouling observed on sponges order Verongida. Sponges Verongida consistently produce these types bromotyrosine-derived secondary metabolites. Previously reported antifouling data for barnacle Balanus amphitrite(EC50 = 12.2 microM) support results here that compound may be a antifoulant (EC50 10.4 microM). The phytotoxic activity toward Lemna pausicostata and, most importantly, compound's significant selectivity against macrofouling organisms such mussels suggest utility this naturally derived lead.