Physaloside A, an Acylated Sucrose Ester from Physalis viscosa

• DOI: 10.1021/np049746r
• Publication Date: 2005-08-16T16:38:30Z
• Authors: Simon P. B. Ovenden; Jin Yu; Jill Bernays; Soo San Wan; Larissa J. Christ...; Gian Sberna; R. Murray Tait; Howard G. Wildman; Dominique Lebeller; John Lowther; Neville G. Walsh; Barbara M. Meurer...
• Keywords: Sucrose; Plants, Medicinal; Molecular Structure; Physalis; Australia; Esters; Microbial Sensitivity Tests; Gram-Positive Bacteria; 01 natural sciences; 0104 chemical sciences; Drug Screening Assays, Antitumor; Nuclear Magnetic Resonance, Biomolecular

Chemical investigations of the crude MeOH extract of Physalis viscosa led to the identification of the novel acylated sucrose ester physaloside A (1). The structure of 1 was determined by 2D NMR analysis, and the absolute configuration was determined by chemical degradation and comparison with authentic standards.