Cytotoxic and Antimicrobial Benzophenones from the Leaves of Tovomita longifolia

• DOI: 10.1021/np050338c
• Publication Date: 2006-03-24T05:27:46Z
• Authors: Marisín Pecchio; Pablo N. Solís; José L. López-Pérez; Yelkaira Vásquez; Nelson Rodríguez; Dionisio Olmedo; Mireya Correa; Arturo San Feliciano; Mahabir P. Gupta
• Keywords: Mycobacterium smegmatis

Bioassay-guided fractionation of the chloroform and ethanol extracts Tovomita longifolia leaves using cytotoxic antimicrobial assays resulted in isolation four new benzophenones, (E)-3-(2-hydroxy-7-methyl-3-methyleneoct-6-enyl)-2,4,6-trihydroxybenzophenone (1), (E)-3-(6-hydroxy-3,7-dimethylocta-2,7-dienyl)-2,4,6-trihydroxybenzophenone (2), 8-benzoyl-2-(4-methylpenten-3-yl)chromane-3,5,7-triol (3), 5-benzoyl-1,1,4a-trimethyl-2,3,4,4a,9,9a-hexahydro-1H-xanthene-6,8-diol (4), two known 4-geranyloxy-2,6-dihydroxybenzophenone (5) 3-geranyl-2,4,6-trihydroxybenzophenone (6). The structures 1−4 were established by spectroscopic means molecular modeling calculations. Compounds 1 3−5 demonstrated activities against breast (MCF-7), central nervous system (SF-268), lung (H-460) human cancer cell lines, while compounds 3−6 showed activity Klebsiella pneumoniae, Mycobacterium smegmatis, Pseudomonas aeruginosa, Salmonella gallinarum, Staphylococcus aureus.