Metachromins U–W: Cytotoxic Merosesquiterpenoids from an Australian Specimen of the Sponge Thorecta reticulata

Molecular Structure Antineoplastic Agents Marine Biology 01 natural sciences Porifera 0104 chemical sciences Animals Humans Drug Screening Assays, Antitumor HT29 Cells Nuclear Magnetic Resonance, Biomolecular Sesquiterpenes
DOI: 10.1021/np200041v Publication Date: 2011-04-22T14:16:26Z
ABSTRACT
Three new merosesquiterpenoids, metachromins U, V, and W (1-3), were isolated from a specimen of the marine sponge Thorecta reticulata collected off Hunter Island, Tasmania, Australia. Structures of the new compounds were elucidated through extensive NMR investigations and comparison with literature values. The cytotoxicities of 1-3 were assessed against a panel of human tumor cell lines (SF-268, H460, MCF-7, and HT-29) and a mammalian cell line (CHO-K1). All compounds were found to have 50% growth inhibition activities in the range 2.1-130 μM, with 2 being the most active (GI50 2.1-10 μM).
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