Metachromins U–W: Cytotoxic Merosesquiterpenoids from an Australian Specimen of the Sponge Thorecta reticulata
Molecular Structure
Antineoplastic Agents
Marine Biology
01 natural sciences
Porifera
0104 chemical sciences
Animals
Humans
Drug Screening Assays, Antitumor
HT29 Cells
Nuclear Magnetic Resonance, Biomolecular
Sesquiterpenes
DOI:
10.1021/np200041v
Publication Date:
2011-04-22T14:16:26Z
AUTHORS (7)
ABSTRACT
Three new merosesquiterpenoids, metachromins U, V, and W (1-3), were isolated from a specimen of the marine sponge Thorecta reticulata collected off Hunter Island, Tasmania, Australia. Structures of the new compounds were elucidated through extensive NMR investigations and comparison with literature values. The cytotoxicities of 1-3 were assessed against a panel of human tumor cell lines (SF-268, H460, MCF-7, and HT-29) and a mammalian cell line (CHO-K1). All compounds were found to have 50% growth inhibition activities in the range 2.1-130 μM, with 2 being the most active (GI50 2.1-10 μM).
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (23)
CITATIONS (22)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....