Antimalarial Activity of Physalins B, D, F, and G

Mice, Inbred BALB C 0303 health sciences Physalis Plasmodium berghei Plasmodium falciparum Parasitemia Malaria 3. Good health Antimalarials Mice 03 medical and health sciences Animals Secosteroids Immunosuppressive Agents
DOI: 10.1021/np200260f Publication Date: 2011-09-28T15:06:48Z
ABSTRACT
The antimalarial activities of physalins B, D, F, and G (1-4), isolated from Physalis angulata, were investigated. In silico analysis using the similarity ensemble approach (SEA) database predicted the antimalarial activity of each of these compounds, which were shown using an in vitro assay against Plasmodium falciparum. However, treatment of P. berghei-infected mice with 3 increased parasitemia levels and mortality, whereas treatment with 2 was protective, causing a parasitemia reduction and a delay in mortality in P. berghei-infected mice. The exacerbation of in vivo infection by treatment with 3 is probably due to its potent immunosuppressive activity, which is not evident for 2.
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