Antimalarial Activity of Physalins B, D, F, and G

• DOI: 10.1021/np200260f
• Publication Date: 2011-09-28T15:06:48Z
• Authors: Matheus S. Sá; Maria N. de Menezes; Antoniana U. Krettli; Ivone M. Ribeiro; Therezinha C. B. ...; Ricardo Ribeiro d...; Walter F de Azevedo; Milena B. P. Soares
• Keywords: Plasmodium berghei

The antimalarial activities of physalins B, D, F, and G (1–4), isolated from Physalis angulata, were investigated. In silico analysis using the similarity ensemble approach (SEA) database predicted activity each these compounds, which shown an in vitro assay against Plasmodium falciparum. However, treatment P. berghei-infected mice with 3 increased parasitemia levels mortality, whereas 2 was protective, causing a reduction delay mortality mice. exacerbation vivo infection by is probably due to its potent immunosuppressive activity, not evident for 2.