Antimalarial Activity of Physalins B, D, F, and G
Mice, Inbred BALB C
0303 health sciences
Physalis
Plasmodium berghei
Plasmodium falciparum
Parasitemia
Malaria
3. Good health
Antimalarials
Mice
03 medical and health sciences
Animals
Secosteroids
Immunosuppressive Agents
DOI:
10.1021/np200260f
Publication Date:
2011-09-28T15:06:48Z
AUTHORS (8)
ABSTRACT
The antimalarial activities of physalins B, D, F, and G (1-4), isolated from Physalis angulata, were investigated. In silico analysis using the similarity ensemble approach (SEA) database predicted the antimalarial activity of each of these compounds, which were shown using an in vitro assay against Plasmodium falciparum. However, treatment of P. berghei-infected mice with 3 increased parasitemia levels and mortality, whereas treatment with 2 was protective, causing a parasitemia reduction and a delay in mortality in P. berghei-infected mice. The exacerbation of in vivo infection by treatment with 3 is probably due to its potent immunosuppressive activity, which is not evident for 2.
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