Triterpenoids with Rare Carbon Skeletons from Salvia hydrangea: Antiprotozoal Activity and Absolute Configurations

• DOI: 10.1021/np200559c
• Publication Date: 2011-10-03T14:42:53Z
• Authors: M. Moridi Farimani; M. Babak Bahadori; Salman Taheri; Samad N. Ebrahimi; Stefanie Zimmermann; Reto Brun; Gholamreza Amin; Matthias Hamburger
• Keywords: Antiprotozoal; Absolute Configuration; Trypanosoma brucei rhodesiense; Salvia

Salvadione C (1) and perovskone B (2), two new triterpenoids with rare carbon skeletons, were isolated from an antiplasmodial n-hexane extract of Salvia hydrangea. The absolute configuration was determined by comparison experimental calculated electronic circular dichroism (ECD) spectra. In vitro activity against Plasmodium falciparum K1 strain, Trypanosoma brucei rhodesiense STIB 900 cytotoxicity in rat myoblast (L6) cells determined. Compounds 1 2 showed activity, IC50 values 1.43 0.18 μM selectivity indices (SI) 86.2 69.6, respectively. T. found to be 4.33 15.92 μM,