Dibenzocyclooctadiene Lignans fromKadsura polyspermaand Their Antineurodegenerative Activities

• DOI: 10.1021/np200937h
• Publication Date: 2012-02-13T14:37:14Z
• Authors: Ke Dong; Jian-Xin Pu; Hai-Yan Zhang; Xue Du; Xiao-Nian Li; Juan Zou; Jian-Hong Yang; Wei Zhao; Xi-Can Tang; Han-Dong Sun
• Keywords: Molecular Structure; Plant Stems; Molecular Conformation; Hydrogen Peroxide; Crystallography, X-Ray; 01 natural sciences; Lignans; Rats; 3. Good health; 0104 chemical sciences; Cyclooctanes; Neuroprotective Agents; Kadsura; Animals; Nuclear Magnetic Resonance, Biomolecular; Drugs, Chinese Herbal

Eleven new dibenzocyclooctadiene lignans, polysperlignans A-K (1-11), and eight known analogues (12-19) were isolated from the stems of Kadsura polysperma. Their structures absolute configurations established using a combination MS, NMR, CD, single-crystal X-ray diffraction techniques. Selected compounds evaluated for activity against β-amyloid- or hydrogen peroxide-induced neurotoxicity on PC12 cells, 1, 2, 4, 5, 13, 16 showed statistically significant neuroprotective effects in these vitro assays.