Mycaperoxides F and G and a Related Norterpene Ketone from Southern Australian Marine Sponges, Mycale Species

• DOI: 10.1021/np970484l
• Publication Date: 2002-07-26T05:24:06Z
• Authors: Robert J. Capon; Simone J. Rochfort; Simon P. B. Ovenden; Robert P. Metzger
• Keywords: Chemistry; Plant Sciences; Applied; Cyclic Peroxides; Pharmacology & Pharmacy; Medicinal; 01 natural sciences; 0104 chemical sciences

Investigation of two southern Australian marine sponges, Mycale spp., resulted in isolation of the known norsesterterpene mycaperoxide F methyl ester (5) together with a new norsesterterpene mycaperoxide G methyl ester (10) and a new norterpene ketone 11. All structures were secured by spectroscopic analysis and chemical derivatization. The absolute stereochemistry previously assigned to 5 by application of the Horeau procedure has been revised by application of the Mosher procedure.